PHAGO Publications

28/08/2018

Human Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Deficits in Phagocytosis

Cell Reports - P. Garcia-Reitboeck, A. Phillips, T.M. Piers, C. Villegas-Llerena, M. Butler, A. Mallach, C. Rodrigues, C.E. Arber, A. Heslegrave, H. Zetterberg, H. Neumann, S. Neame, H. Houlden, J. Hardy and J.M. Pocock

P. Garcia-Reitboeck, A. Phillips, T.M. Piers, C. Villegas-Llerena, M. Butler, A. Mallach, C. Rodrigues, C.E. Arber, A. Heslegrave, H. Zetterberg, H. Neumann, S. Neame, H. Houlden, J. Hardy and J.M. Pocock

DOI 10.1016/j.celrep.2018.07.094

 

In Brief

Garcia-Reitboeck et al. describe the generation of human induced pluripotent stem cell-derived microglia-like cells from patients with early-onset dementia caused by variants in the immune receptor gene TREM2. They observed functional deficits in TREM2 variant cells, including reduced soluble TREM2 secretion, selectively reduced phagocytosis of apoptotic neuronal cells, and a deficit in migratory capacity.

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This project has received funding from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement No 115976. This Joint Undertaking receives support from the European Union's Horizon 2020 research and innovation programme and EFPIA companies.

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This project has received funding from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement No 115976. This Joint Undertaking receives support from the European Union's Horizon 2020 research and innovation programme and EFPIA companies.