Prof. Jochen Walter - Universitätsklinikum Bonn (UKB)
Prof. Jochen Walter is working at the University Hospital of Bonn, Germany
Work performed in PHAGO
“We are interested in signalling pathways of TREM2, and the pathophysiological implications for Alzheimer’s disease. In the PHAGO project, we are developing a reporter cell system for TREM2 in order to identify and characterize modulators of TREM2 signalling.”
Interesting readings and/or reviews about our work
1) "This study describes the identification and characterization of a novel TREM2 variant in familial clustering of dementia.”
"A rare heterozygous TREM2 coding variant identified in familial clustering of dementia affects an intrinsically disordered protein region and function of TREM2"
Karsak, M., K. Glebov, M. Scheffold, T. Bajaj, A. Kawalia, I. Karaca, S. Rading, J. Kornhuber, O. Peters, M. Diez-Fairen, L. Frölich, M. Hüll, J. Wiltfang, M. Scherer, S. Riedel-Heller, A. Schneider, M.T. Heneka, K. Fliessbach, A. Sharaf, H. Thiele, M. Lennarz, F. Jessen, W. Maier, C. Kubisch, Z. Ignatova, P.Nürnberg, P. Pastor, J. Walter, Alfredo Ramirez. Hum Mutat (2019)
2) "In this study, we demonstrate the proteolytic processing of ephrin B2 by γ-secretase and the functional implications in microglia."
"Intramembranous processing by γ-secretase regulates reverse signaling of ephrin-B2 in migration of microglia"
Kemmerling, N., P. Wunderlich, S. Theil, B. Linnartz-Gerlach, N. Hersch, B. Hoffmann, M.T. Heneka, B. de Strooper, H. Neumann, J. Walter. Glia (2017)
3) "This publication shows the importance of intramembrane proteolysis by γ-secretase in the signalling activity of TREM2."
"Functional involvement of γ-secretase in signaling of the triggering receptor expressed on myeloid cells-2 (TREM2)."
Glebov, K., P. Wunderlich, I. Karaca, J. Walter, Neuroinflammation (2016)
4) "This review summarized the knowledge on TREM2 and its implication in neurodegenerative diseases.”
"Triggering receptor expressed on myeloid cells 2: A molecular link between neuroinflammation and neurodegeneration"
Walter, J (J Biol. Chem. (2016)
5)"This study shows the identification of ectodomain shedding and intramembrane cleavage of TREM2"
"Sequential proteolytic processing of the triggering receptor expressed on myeloid cells-2 (TREM2) by ectodomain shedding and γ-secretase dependent intramembranous cleavage"
Wunderlich, P., K. Glebov, N. Kemmerling, N. T. Tien, H. Neumann, J. Walter. J Biol. Chem. (2013)