Prof. Guy Brown - University of Cambridge (UCAM)
Prof. Guy Brown is working at the University of Cambridge, UK
Work performed in PHAGO
“Our group is mainly looking at TREM2 and sTREM2 functions in work packages 2.2. and 2.3”
Interesting readings and/or reviews about our work
1) "Reviews the evidence that neurodegeneration is due to endotoxin.”
"The endotoxin hypothesis of neurodegeneration"
Brown GC. J Neuroinflammation (2019)
2) "Paper showing that galectin-3 activates TREM2 and is required for amyloid pathology"
"Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer's disease"
Boza-Serrano A, Ruiz R, Sanchez-Varo R, García-Revilla J, Yang Y, Jimenez-Ferrer I, Paulus A, Wennström M, Vilalta A, Allendorf D, Davila JC, Stegmayr J, Jiménez S, Roca-Ceballos MA, Navarro-Garrido V, Swanberg M, Hsieh CL, Real LM, Englund E, Linse S, Leffler H, Nilsson UJ, Brown GC, Gutierrez A, Vitorica J, Venero JL, Deierborg T. Acta Neuropathol. (2019)
3) "Describes new method to knockdown gene expression in microglia, including TREM2 and CD33"
"Effective Knockdown of Gene Expression in Primary Microglia With siRNA and Magnetic Nanoparticles Without Cell Death or Inflammation. "
Carrillo-Jimenez A, Puigdellívol M, Vilalta A, Venero JL, Brown GC, StGeorge-Hyslop P, Burguillos MA. Front Cell Neurosci (2018)
4) "Reviews how neurons die, particularly in Alzheimer’s disease.”
"Neuronal Cell Death"
Fricker M, Tolkovsky AM, Borutaite V, Coleman M, Brown GC. Physiol Rev (2018)
5)"Reviews how microglial phagocytosis prunes neurons"
"Neurophagy, the phagocytosis of live neurons and synapses by glia, contributes to brain development and disease"
Vilalta A, Brown GC. FEBS J (2018)