Prof. Harald Neumann - Coordinator
Prof. Harald Neumann is working at the University Hospital of Bonn, Germany
Work performed in PHAGO
“Our group is identifying CD33 receptor-related signalling pathways in microglia and analysing the function of human microglial CD33.”
Interesting readings and/or reviews about our work
1) Publication suggests that TREM2 could have detrimental effects on neurons in aging mice without any disease process.
"TREM2 triggers microglial density and age-related neuronal loss".
Linnartz-Gerlach, B., Bodea, L.G., Klaus, C., Ginolhac, A., Halder, R., Sinkkonen, L., Walter, J., Colonna, M., Neumann, H. (2019). Glia.
2) Publication shows in an animal model of retinal laser lesion that local application of soluble polysialic acid inhibits phagocytes and protects from vascular damage via the CD33-related SIGLEC11 receptor."
"Polysialic acid blocks mononuclear phagocyte reactivity, inhibits complement activation, and protects from vascular damage in the retina."
Karlstetter, M., Kopatz, J., Aslanidis, A., Shahraz, A., Caramoy, A., Linnartz-Gerlach, B., Lin, Y., Lückoff, A., Fauser, S., Düker, K., Claude, J., Wang, Y., Ackermann, J., Schmidt, T., Hornung, V., Skerka, C., Langmann, T., Neumann, H. (2017). EMBO Mol Med.
3) Publication demonstrates in culture that the CD33-related Siglec-E receptor turns down the neurotoxic oxidative burst of murine microglia.
"Microglial CD33-related Siglec-E inhibits neurotoxicity by preventing the phagocytosis associated oxidative burst."
Claude, J., Linnartz-Gerlach, B., Kudinm A.P., Kunz, W.S., Neumann, H. (2013). J Neuroscience