Work package 2
Pathways, ligands, signaling
In Work package 2 (WP2) PHAGO will identify targets in the TREM2 and CD33-signalling microglial pathway, elucidate the receptor ligands and determine the functional role of CD33 and TREM2-related targets in phagocyte signalling.
The first aim of WP2 is to: i) identify novel AD risk genes within microglial pathways, ii) identify downstream genes/pathways with altered expression by TREM2, CD33 and their variants, and iii) compare the mouse and human TREM2/CD33 pathways in disease and animal model systems. This pathway analysis will help to identify druggable points of intervention and possible potential side effects within the TREM2 and CD33 pathways.
The second aim of WP2 is to identify possible sugar, lipid and protein ligands of TREM2 and CD33 to better understand receptor function and to allow generation of possible agonists/antagonists.